AP-009
Pediatric lymphoma, urban, commercial, under 25 miles
CAR-T · Phase 4, Collection & Preparation · 19 days in stage · 6 barriers, 3 blocking
Diagnosis & Referral
From diagnosis to first contact with an accredited center.
Start ahead · work beginning here for later phases
- Confirm the center’s caregiver requirement and any flexibility · Caregiver & psychosocial clearance · for phase 2
- Start caregiver planning now; explore paid-caregiver and respite options · Caregiver & psychosocial clearance · for phase 2
- Connect family to caregiver stipend / paid-leave resources and advocacy · Caregiver & psychosocial clearance · for phase 2
- Plan bridging early with a standardized protocol; avoid bendamustine before apheresis · Manufacturing / collection & vein-to-vein risk · for phase 4
- Secure subsidized / free housing near the center early · Housing insecurity / relocation burden · for phase 2
Candidacy Evaluation
The work-up that determines whether the center will proceed. Most tests run in parallel and all feed the selection decision.
Start ahead · work beginning here for later phases
- Ask about early leukapheresis + cryopreservation to protect T-cell fitness · Manufacturing / collection & vein-to-vein risk · for phase 4
Coverage & Authorization
Securing payer approval and financial clearance for the specific therapy.
Collection & Preparation
Obtaining the cells and getting the patient ready. This is where CAR-T and allogeneic transplant diverge.
CAR-T track
Shared preparation — in parallel with collection
Treatment
Conditioning, infusion, and the acute monitoring window.
Recovery & Follow-up
Monitoring, transition back home, and long-term survivorship.